As of January 2020, a number of clinical drug trials are recruiting participants. Details about these studies can be found at www.clinicaltrials.gov. Biotech companies also may have a webpage dedicated to the therapy they are studying.
Sponsor: argenx BVBA. A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase 3 Trial to Evaluate the Efficacy, Safety and Tolerability of ARGX-113 (efgartigimod) in Patients With Myasthenia Gravis Having Generalized Muscle Weakness, Active, no longer recruiting (25 US sites) ADAPT
Sponsor: Catalyst Pharmaceuticals. Long Term Safety Study of Amifampridine Phosphate (Firdapse®) in Patients With MuSK Antibody Positive and AChR (Acetylcholine Receptor) Antibody Positive Myasthenia Gravis. www.firdapse.com
Sponsor: Immunovant Sciences GmbH. A Phase 2a, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study with an Open-Label Extenstion of RVT- 1401 in Myasthenia Gravis Patients, Active and recruiting (Sites in AL, AZ, CA, CT, GA, MN, NY, PA, TX) ASCEND
Sponsor: Momenta Pharmaceuticals. A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Efficacy, Pharmacokinetics and Pharmacodynamics of nipocalimab (M281) Administered to Adults With Generalized Myasthenia Gravis, Active and recruiting (29 US sites) Momenta website page
Sponsor: Ra Pharmaceuticals. A Phase 3, Multicenter, Randomized, Double Blind, Placebo-Controlled Study to Confirm the Safety, Tolerability, and Efficacy of Zilucoplan in Subjects With Generalized Myasthenia Gravis. Active and recruiting (31 sites) RA Pharma website page (RAISE)
Sponsor: Takeda. A Phase 2, Randomized, Placebo-Controlled Study to Evaluate Safety, Tolerability, and Efficacy of TAK-079 in Patients With Generalized Myasthenia Gravis, active and recruiting (Sites in CA, CO, FL, GA, IL, KS, MI, NC, NY, OH, TX, WI).
Sponsor: UCB Biopharma S.P.R.L. A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating Efficacy and Safety of Rozanolixizumab in Adult Patients With Generalized Myasthenia Gravis. Recruiting (17 US sites) Visit MycarinGstudy.
Sponsor: Alexion Pharmaceuticals. An Open-Label, Multicenter Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Eculizumab in Pediatric Patients with Refractory Generalized Myasthenia Gravis. Active and recruiting
Sponsor: Alexion Pharmaceuticals. A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of Ravulizumab (Ultomiris® in Complement-Inhibitor-Naïve Adult Patients With Generalized Myasthenia Gravis. Active and recruiting (47 US sites) Ultomiris
Other MG-related clinical trials listed in www.clinicaltrials.gov address myasthenia and exercise, Decartes-08 CAR-T Cells, a magnetic levator prosthesis to ease ocular symptoms, and stem cell transplant.